Compactible powders of omega-3 and β-cyclodextrin

Tina Lien Vestland; Øyvind Jacobsen; Sverre Arne Sande; Astrid Hilde Myrset; Jo Klaveness

doi:10.1016/j.foodchem.2015.03.132

Compactible powders of omega-3 and β-cyclodextrin

Food Chem. 2015 Oct 15:185:151-8. doi: 10.1016/j.foodchem.2015.03.132. Epub 2015 Apr 4.

Authors

Tina Lien Vestland¹, Øyvind Jacobsen², Sverre Arne Sande³, Astrid Hilde Myrset⁴, Jo Klaveness⁵

Affiliations

¹ Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. Electronic address: tina.lien.vestland@omegatri.no.
² Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, 0315 Oslo, Norway.
³ School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
⁴ Tåsen Terrasse 4A, 0873 Oslo, Norway.
⁵ Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.

PMID: 25952853
DOI: 10.1016/j.foodchem.2015.03.132

Abstract

Omega-3 fatty acids are used in both nutraceuticals and pharmaceuticals in the form of triglycerides and ethyl esters. Administration forms available for omega-3 include bulk oil, soft gel capsules, emulsions and some powder compositions. Cyclodextrins are substances well known for their ability to encapsulate lipophilic molecules. In the present work, powders loaded with omega-3 oil, ranging from 10 to 40% (w/w), have been prepared by vacuum drying, freeze drying or spray granulation of aqueous mixtures of omega-3 oil and β-cyclodextrin. The powders were found to be partially crystalline by powder X-ray diffraction and to contain crystalline phases not present in pure β-cyclodextrin, indicating true complexation. The compactibility of the powders has been explored, revealing that a dry and compactible powder can be prepared from various omega-3 oils and β-cyclodextrin. Spray granulation was found to be the superior drying method for the preparation of compactible powders.

Keywords: Cyclodextrin; DHA; EPA; Fish oil; Omega-3; Powder; Tablets.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Desiccation
Drug Compounding
Fatty Acids, Omega-3 / chemistry*
Food Handling
Freeze Drying
Powders / chemistry
X-Ray Diffraction
beta-Cyclodextrins / chemistry*

Substances

Fatty Acids, Omega-3
Powders
beta-Cyclodextrins
betadex