OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis

G E Gold; F Cicuttini; M D Crema; F Eckstein; A Guermazi; R Kijowski; T M Link; E Maheu; J Martel-Pelletier; C G Miller; J-P Pelletier; C G Peterfy; H G Potter; F W Roemer; D J Hunter

doi:10.1016/j.joca.2015.03.004

OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis

Osteoarthritis Cartilage. 2015 May;23(5):716-31. doi: 10.1016/j.joca.2015.03.004.

Authors

G E Gold¹, F Cicuttini², M D Crema³, F Eckstein⁴, A Guermazi⁵, R Kijowski⁶, T M Link⁷, E Maheu⁸, J Martel-Pelletier⁹, C G Miller¹⁰, J-P Pelletier⁹, C G Peterfy¹¹, H G Potter¹², F W Roemer¹³, D J Hunter¹⁴

Affiliations

¹ Departments of Radiology, Bioengineering, and Orthopaedic Surgery, Stanford University, Stanford, CA, USA. Electronic address: gold@stanford.edu.
² School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne 3004, Australia.
³ Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, SP, Brazil.
⁴ Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria & Chondrometrics GmbH, Ainring, Germany.
⁵ Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
⁶ Department of Radiology, University of Wisconsin School of Medicine, Madison, WI, USA.
⁷ Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
⁸ Rheumatology Department, Hôpital Saint-Antoine, AP-HP, Paris, France.
⁹ Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
¹⁰ BioClinica, Newtown, PA, USA.
¹¹ Spire Sciences, Inc., Boca Raton, FL, USA.
¹² Department of Radiology, Hospital for Special Surgery, New York, NY, USA.
¹³ Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, University of Erlangen-Nuremberg, Germany.
¹⁴ Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, NSW, Australia.

Abstract

Imaging of hip in osteoarthritis (OA) has seen considerable progress in the past decade, with the introduction of new techniques that may be more sensitive to structural disease changes. The purpose of this expert opinion, consensus driven recommendation is to provide detail on how to apply hip imaging in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, artifacts associated with various MRI sequences); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, and validity); recommendations for trials; and research recommendations.

Keywords: Clinical trial guidelines; Hip osteoarthritis; Imaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Clinical Trials as Topic / standards*
Diagnostic Imaging / standards*
Disease Progression
Humans
Osteoarthritis, Hip / diagnosis*
Practice Guidelines as Topic*

Abstract

Publication types

MeSH terms

Grants and funding