Abstract
Prevention of implant loosening and infection is crucial to orthopedic and dental surgeries. In this work, the surface of stainless steel (SS) was modified by silver-sourced plasma immersion ion implantation (Ag-PIII). Metallic silver nanoparticles with various diameters and distributions were fabricated on the SS surfaces after treatment with Ag-PIII for 0.5 and 1.5 h, respectively. The osteogenic activity and antimicrobial properties of SS before and after Ag-PIII treatment were evaluated using in vitro and in vivo tests. The results demonstrated that Ag-PIII treatment not only promoted the antibacterial activity of SS but also enhanced the osteogenic differentiation of human bone marrow stromal cells.
Keywords:
antimicrobial; osteogenic; plasma immersion ion implantation; silver; stainless steel.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / chemistry
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Bacterial Physiological Phenomena / drug effects*
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Cell Differentiation / drug effects
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Cell Differentiation / physiology
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Cell Survival / drug effects
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Cells, Cultured
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Heavy Ions
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Humans
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Materials Testing
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Mesenchymal Stem Cells / cytology*
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Mesenchymal Stem Cells / drug effects
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Metal Nanoparticles / administration & dosage*
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Metal Nanoparticles / chemistry
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Osteoblasts / cytology*
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Osteoblasts / drug effects
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Osteogenesis / drug effects
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Osteogenesis / physiology
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Plasma Gases / chemistry
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Silver / chemistry
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Silver / pharmacology*
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Stainless Steel / chemistry*
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Stainless Steel / radiation effects
Substances
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Anti-Infective Agents
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Plasma Gases
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Stainless Steel
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Silver