Abstract
A new generation of photothermal theranostic agents based on assembling 6 nm gold nanoparticles (AuNPs) is developed by using a novel comb-like amphipathic polymer as the template. The small AuNPs are assembled into DOX@gold nanomicelles, which show strong absorbance in the near-infrared region, for multimodal bioimaging and highly effective in vivo chemotherapy and photothermal therapy.
Keywords:
clearance; comb-like polymers; gold nanoparticles; self-assembly; theranostics.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenocarcinoma / pathology
-
Adenocarcinoma / therapy
-
Animals
-
Biocompatible Materials* / therapeutic use
-
Biocompatible Materials* / toxicity
-
Cell Survival
-
Feasibility Studies
-
Fibroblasts / physiology
-
Gold Compounds* / therapeutic use
-
Gold Compounds* / toxicity
-
Humans
-
Hydrophobic and Hydrophilic Interactions
-
Laser Therapy / instrumentation
-
MCF-7 Cells
-
Metal Nanoparticles* / therapeutic use
-
Metal Nanoparticles* / toxicity
-
Methacrylates / toxicity
-
Mice
-
Micelles*
-
Multimodal Imaging / instrumentation
-
Neoplasm Transplantation
-
Phototherapy / instrumentation
-
Polyhydroxyethyl Methacrylate / toxicity
-
Polymers* / therapeutic use
-
Polymers* / toxicity
-
Theranostic Nanomedicine / instrumentation
-
Umbilical Veins / cytology
-
Umbilical Veins / physiology
Substances
-
Biocompatible Materials
-
Gold Compounds
-
Methacrylates
-
Micelles
-
Polymers
-
poly(2-(2-methoxyethoxy)ethyl methacrylate)
-
Polyhydroxyethyl Methacrylate