Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance

Adv Mater. 2015 Jun 24;27(24):3645-53. doi: 10.1002/adma.201501420. Epub 2015 May 6.

Abstract

A new generation of photothermal theranostic agents based on assembling 6 nm gold nanoparticles (AuNPs) is developed by using a novel comb-like amphipathic polymer as the template. The small AuNPs are assembled into DOX@gold nanomicelles, which show strong absorbance in the near-infrared region, for multimodal bioimaging and highly effective in vivo chemotherapy and photothermal therapy.

Keywords: clearance; comb-like polymers; gold nanoparticles; self-assembly; theranostics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy
  • Animals
  • Biocompatible Materials* / therapeutic use
  • Biocompatible Materials* / toxicity
  • Cell Survival
  • Feasibility Studies
  • Fibroblasts / physiology
  • Gold Compounds* / therapeutic use
  • Gold Compounds* / toxicity
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Laser Therapy / instrumentation
  • MCF-7 Cells
  • Metal Nanoparticles* / therapeutic use
  • Metal Nanoparticles* / toxicity
  • Methacrylates / toxicity
  • Mice
  • Micelles*
  • Multimodal Imaging / instrumentation
  • Neoplasm Transplantation
  • Phototherapy / instrumentation
  • Polyhydroxyethyl Methacrylate / toxicity
  • Polymers* / therapeutic use
  • Polymers* / toxicity
  • Theranostic Nanomedicine / instrumentation
  • Umbilical Veins / cytology
  • Umbilical Veins / physiology

Substances

  • Biocompatible Materials
  • Gold Compounds
  • Methacrylates
  • Micelles
  • Polymers
  • poly(2-(2-methoxyethoxy)ethyl methacrylate)
  • Polyhydroxyethyl Methacrylate