Mast cell and autoimmune diseases

Yunzhi Xu; Guangjie Chen

doi:10.1155/2015/246126

Mast cell and autoimmune diseases

Mediators Inflamm. 2015:2015:246126. doi: 10.1155/2015/246126. Epub 2015 Apr 5.

Authors

Yunzhi Xu¹, Guangjie Chen¹

Affiliation

¹ Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China.

Abstract

Mast cells are important in innate immune system. They have been appreciated as potent contributors to allergic reaction. However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis. Here we review the current stage of knowledge about mast cells in autoimmune diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arthritis, Rheumatoid / immunology
Autoimmune Diseases / immunology*
Cell Movement
Chronic Disease
Diabetes Mellitus, Type 1 / immunology
Enzyme Inhibitors / chemistry
Humans
Hypersensitivity / immunology
Immunity, Innate
Inflammation / immunology
Mast Cells / immunology*
Mice
Mice, Transgenic
Multiple Sclerosis / immunology
T-Lymphocytes, Regulatory / cytology
Th17 Cells / cytology
Urticaria / immunology

Substances

Enzyme Inhibitors