Eunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta

Tzu-Zin Huang; Bo-Wei Chen; Chiung-Yao Huang; Tsong-Long Hwang; Chokkalingam Uvarani; Chang-Feng Dai; Ping-Jyun Sung; Jui-Hsin Su; Jyh-Horng Sheu

doi:10.3390/md13052757

Eunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta

Mar Drugs. 2015 Apr 30;13(5):2757-69. doi: 10.3390/md13052757.

Authors

Tzu-Zin Huang¹, Bo-Wei Chen², Chiung-Yao Huang³, Tsong-Long Hwang^{4

5}, Chokkalingam Uvarani^{6

7}, Chang-Feng Dai⁸, Ping-Jyun Sung^{9

10}, Jui-Hsin Su^{11

12}, Jyh-Horng Sheu^{13

14

15

16

17}

Affiliations

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. slime112229@gmail.com.
² Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. a6152761@yahoo.com.tw.
³ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. betty8575@yahoo.com.tw.
⁴ Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁵ Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁶ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. uvaranichem@gmail.com.
⁷ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. uvaranichem@gmail.com.
⁸ Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan. corallab@ntu.edu.tw.
⁹ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁰ Department of Life Science and Institute of Biotechnology and Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹¹ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
¹² Department of Life Science and Institute of Biotechnology and Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
¹³ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁴ Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁵ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁶ Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. sheu@mail.nsysu.edu.tw.
¹⁷ Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.

Abstract

Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology
Cell Proliferation / drug effects
Diterpenes / chemistry*
Diterpenes / pharmacology*
Humans
Neutrophils / drug effects
Neutrophils / metabolism
Pancreatic Elastase / metabolism
Superoxides / metabolism

Substances

Anti-Inflammatory Agents
Diterpenes
eunicellin
Superoxides
Pancreatic Elastase