Vitamin B6 improves the immunogenicity of cisplatin-induced cell death

Fernando Aranda; Norma Bloy; Lorenzo Galluzzi; Guido Kroemer; Laura Senovilla

doi:10.4161/21624011.2014.955685

Vitamin B6 improves the immunogenicity of cisplatin-induced cell death

Oncoimmunology. 2014 Dec 13;3(9):e955685. doi: 10.4161/21624011.2014.955685. eCollection 2014 Oct.

Authors

Fernando Aranda¹, Norma Bloy¹, Lorenzo Galluzzi¹, Guido Kroemer², Laura Senovilla³

Affiliations

¹ Equipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris 5 ; Sorbonne Paris Cité , Paris, France ; INSERM U1138; Paris, France ; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France.
² Equipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; Université Paris Descartes/Paris 5 ; Sorbonne Paris Cité , Paris, France ; INSERM U1138; Paris, France ; Metabolomics and Cell Biology platforms; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France ; Pôle de Biologie, Hôpital Européen Georges Pompidou ; AP-HP ; Paris, France.
³ Equipe 11 labelisée par la Ligue Nationale contre le cancer; Centre de Recherche des Cordeliers ; Paris, France ; INSERM U1138; Paris, France ; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France ; Metabolomics and Cell Biology platforms; Gustave Roussy Comprehensive Cancer Center ; Villejuif, France ; INSERM U1015; Villejuif, France.

Abstract

We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.

Keywords: ATP; CDDP, cis-diamminedichloroplatinum(II); HMGB1; NSCLC, non-small cell lung carcinoma; PDXK; PDXK, pyridoxal kinase; PN, pyridoxine; apoptosis; autophagy; calreticulin; endoplasmic reticulum stress.

Publication types

Research Support, Non-U.S. Gov't