Lipid in T-cell receptor transmembrane signaling

Wei Wu; Chengsong Yan; Xiaoshan Shi; Lunyi Li; Wanli Liu; Chenqi Xu

doi:10.1016/j.pbiomolbio.2015.04.004

Lipid in T-cell receptor transmembrane signaling

Prog Biophys Mol Biol. 2015 Sep;118(3):130-8. doi: 10.1016/j.pbiomolbio.2015.04.004. Epub 2015 May 1.

Authors

Wei Wu¹, Chengsong Yan¹, Xiaoshan Shi¹, Lunyi Li¹, Wanli Liu², Chenqi Xu³

Affiliations

¹ National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
² MOE Key Laboratory of Protein Science, School of Life Sciences, Institute for Immunology of Tsinghua University, Tsinghua University, Beijing 100084, China.
³ National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 200031, China. Electronic address: cqxu@sibcb.ac.cn.

PMID: 25937467
DOI: 10.1016/j.pbiomolbio.2015.04.004

Abstract

T-cell receptor (TCR) is a key receptor in the immune system that can recognize antigen and initiate adaptive immune response. TCR activity needs to be regulated in a precise manner to trigger sufficient response to foreign pathogens but avoid unnecessary harm to the host. Despite of its importance, the molecular mechanism of TCR transmembrane signaling still remains elusive. Emerging studies show that lipid can play sophisticated roles in regulating the structure and function of TCR. This review mainly discusses how acidic phospholipids regulate TCR signaling through ionic protein-lipid interaction.

Keywords: Acidic phospholipid; Ionic protein-lipid interaction; T-cell receptor; Tyrosine phosphorylation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Animals
CD3 Complex / chemistry
CD3 Complex / metabolism
Cell Membrane / metabolism*
Humans
Lipid Metabolism*
Molecular Sequence Data
Phosphorylation
Protein Structure, Tertiary
Receptors, Antigen, T-Cell / metabolism*

Substances

CD3 Complex
Receptors, Antigen, T-Cell