The Distilbène® story is a dramatic episode which belongs to the history of medicine. It provided several useful lessons such as the importance of evidence-based medicine and the hazard to develop treatments during pregnancy without careful animal verifications. However, this experience has also provided unexpected progress by suggesting new pathophysiological concepts: fetal programming of adult diseases and/or transgenerational transmission of environmental effects through epigenetic modifications.
Keywords: Adénocarcinome vaginal; Distilbène(®); Effet transgénérationnel; Endocrine disruptors; Exposition fœtale; Fetal exposure; Hypospadias; Perturbateurs endocriniens; Transgenerational effect; Vaginal adenocarcinoma.
Copyright © 2015. Published by Elsevier Masson SAS.