Abstract
Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antibodies, Viral / blood
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Chickens
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China
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Drug Carriers / administration & dosage*
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Hemagglutination Inhibition Tests
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Hemagglutinin Glycoproteins, Influenza Virus / genetics
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Hemagglutinin Glycoproteins, Influenza Virus / immunology*
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Influenza A Virus, H5N1 Subtype / genetics
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Influenza A Virus, H5N1 Subtype / immunology
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Influenza A Virus, H7N9 Subtype / genetics
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Influenza A Virus, H7N9 Subtype / immunology
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Influenza Vaccines / administration & dosage
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Influenza Vaccines / genetics
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Influenza Vaccines / immunology*
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Influenza in Birds / immunology
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Influenza in Birds / prevention & control*
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Newcastle disease virus / genetics*
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Newcastle disease virus / growth & development
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Survival Analysis
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / genetics
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Vaccines, Attenuated / immunology
Substances
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Antibodies, Viral
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Drug Carriers
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Hemagglutinin Glycoproteins, Influenza Virus
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Influenza Vaccines
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Vaccines, Attenuated
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hemagglutinin, avian influenza A virus