By employing mesoporous carbon (MC), active carbon (AC), XC-72 and CMK-3 as the supports, we report carbon supported IrFe catalysts in the application of preferential oxidation of CO for the first time. The optimal activity was obtained over IrFe/MC, with a CO conversion of 83.5% at 80 degrees C. This activity became even better in the second run and achieved a CO conversion of 89.5% at 60 degrees C. The as-prepared catalysts have been characterized by N2 sorption isotherms, X-ray diffraction, high-resolution scanning electron microscopy, transmission electron microscopy, Mössbauer spectroscopy, X-ray photoelectron spectroscopy and H2 temperature programmed reduction. The promising PROX performance over the IrFe/MC can be attributed to the intrinsic surface properties of MC and its specific interaction with metal species.