CHOgenome.org 2.0: Genome resources and website updates

Biotechnol J. 2015 Jul;10(7):931-8. doi: 10.1002/biot.201400646. Epub 2015 Apr 28.

Abstract

Chinese hamster ovary (CHO) cells are a major host cell line for the production of therapeutic proteins, and CHO cell and Chinese hamster (CH) genomes have recently been sequenced using next-generation sequencing methods. CHOgenome.org was launched in 2011 (version 1.0) to serve as a database repository and to provide bioinformatics tools for the CHO community. CHOgenome.org (version 1.0) maintained GenBank CHO-K1 genome data, identified CHO-omics literature, and provided a CHO-specific BLAST service. Recent major updates to CHOgenome.org (version 2.0) include new sequence and annotation databases for both CHO and CH genomes, a more user-friendly website, and new research tools, including a proteome browser and a genome viewer. CHO cell-line specific sequences and annotations facilitate cell line development opportunities, several of which are discussed. Moving forward, CHOgenome.org will host the increasing amount of CHO-omics data and continue to make useful bioinformatics tools available to the CHO community.

Keywords: Bioinformatics; Biomanufacturing; CHO cell; Genomics; Systems biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • CHO Cells*
  • Cell Engineering*
  • Cell- and Tissue-Based Therapy
  • Computational Biology*
  • Cricetinae
  • Cricetulus
  • Databases, Genetic
  • Databases, Nucleic Acid
  • Genome
  • High-Throughput Nucleotide Sequencing*
  • Humans