Screening and detection of hepatocellular carcinoma

Heather N Simpson; Brendan M McGuire

doi:10.1016/j.cld.2015.01.004

Screening and detection of hepatocellular carcinoma

Clin Liver Dis. 2015 May;19(2):295-307. doi: 10.1016/j.cld.2015.01.004. Epub 2015 Feb 28.

Authors

Heather N Simpson¹, Brendan M McGuire²

Affiliations

¹ The University of Alabama School of Medicine, Department of Medicine, Division of Gastroenterology & Hepatology, Boshell Diabetes Building, 1808 7th Avenue South, Birmingham, AL 35233, USA.
² The University of Alabama School of Medicine, Department of Medicine, Division of Gastroenterology & Hepatology, Boshell Diabetes Building, 1808 7th Avenue South, Birmingham, AL 35233, USA. Electronic address: bmcguire@uab.edu.

PMID: 25921664
DOI: 10.1016/j.cld.2015.01.004

Abstract

The increasing incidence of hepatocellular carcinoma (HCC) has led to the need to identify patients at risk for HCC so that a program of screening can be undertaken. Screening for HCC has led to earlier diagnosis of tumors and thus has aided in initiating optimal medical treatment earlier in the disease course. Advances in radiological techniques and the identification of more accurate serum tests to diagnose HCC continue to be important areas of study and exploration. In particular, there have been efforts to develop new tumor markers to aid in the diagnosis of HCC and guide therapy of tumors.

Keywords: Hepatocellular carcinoma; Screening; Treatment; Tumors.

Publication types

Review

MeSH terms

Biomarkers, Tumor / blood*
Biopsy, Needle / adverse effects
Carcinoma, Hepatocellular / blood
Carcinoma, Hepatocellular / diagnosis*
Carcinoma, Hepatocellular / pathology
Early Detection of Cancer
Humans
Liver / pathology*
Liver Neoplasms / blood
Liver Neoplasms / diagnosis*
Liver Neoplasms / pathology
Neoplasm Seeding*
Population Surveillance*
Risk Factors
alpha-Fetoproteins / metabolism

Substances

Biomarkers, Tumor
alpha-Fetoproteins