Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy

N Lachmann; K Czarnecki; S Brennig; R Phaltane; M Heise; N Heinz; H Kempf; D Dilloo; V Kaever; A Schambach; M Heuser; T Moritz

doi:10.1038/leu.2015.108

Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy

Leukemia. 2015 Nov;29(11):2266-9. doi: 10.1038/leu.2015.108. Epub 2015 Apr 29.

Authors

N Lachmann^{1

2}, K Czarnecki^{1

2}, S Brennig^{1

2}, R Phaltane^{1

2}, M Heise^{1

2}, N Heinz², H Kempf³, D Dilloo⁴, V Kaever⁵, A Schambach^{2

6}, M Heuser⁷, T Moritz^{1

2}

Affiliations

¹ Reprogramming and Gene Therapy Group, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany.
² Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
³ Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
⁴ Department of Pediatric Hematology and Oncology, Center for Child and Adolescent Medicine, Rheinische Friedrich-Wilhelms University, Bonn, Germany.
⁵ Institute of Pharmacology, Research Core Unit Metabolomics, Hannover Medical School, Hannover, Germany.
⁶ Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
⁷ Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

PMID: 25921248
DOI: 10.1038/leu.2015.108

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / adverse effects*
Bone Marrow / drug effects*
Cladribine / adverse effects*
Cytarabine / adverse effects*
Cytidine Deaminase / physiology
Deoxycytidine Kinase / genetics*
Drug Resistance, Neoplasm
Genetic Therapy*
HL-60 Cells
Hematopoietic Stem Cell Transplantation
Humans
Vidarabine / adverse effects
Vidarabine / analogs & derivatives*

Substances

Antineoplastic Agents
Cytarabine
Cladribine
Deoxycytidine Kinase
Cytidine Deaminase
Vidarabine
fludarabine