Abstract
New water-soluble p-tert-butylthiacalix[4]arenes containing peptide and quaternary ammonium fragments in cone and 1,3-alternate conformations were synthesized and characterized. The interaction of the macrocycles with DNA was studied by UV-spectroscopy, DLS and TEM. It was shown that the interaction of the self-associates based on p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with glycine and quaternary ammonium fragments in cone and 1,3-alternate conformations with DNA led to the formation of particles of about 99-192 nm in size.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA / chemistry
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DNA / metabolism*
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Models, Molecular
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Molecular Conformation
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Particle Size
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Peptide Fragments / chemical synthesis*
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Peptide Fragments / chemistry
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Peptide Fragments / metabolism*
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Phenols / chemical synthesis*
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Phenols / chemistry
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Phenols / metabolism*
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Quaternary Ammonium Compounds / chemical synthesis
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Quaternary Ammonium Compounds / chemistry
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Quaternary Ammonium Compounds / metabolism
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Surface-Active Agents / chemical synthesis*
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Surface-Active Agents / chemistry
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Surface-Active Agents / metabolism*
Substances
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Peptide Fragments
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Phenols
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Quaternary Ammonium Compounds
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Surface-Active Agents
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p-tert-butylthiacalix(4)arene
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DNA