Lupus nephritis management guidelines compared

Nephrol Dial Transplant. 2016 Jun;31(6):904-13. doi: 10.1093/ndt/gfv102. Epub 2015 Apr 28.

Abstract

In the past years, many (randomized) trials have been performed comparing the treatment strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines for treating lupus nephritis. These guidelines are European, American and internationally based, with one separate guideline for children. They offer information on different aspects of the management of lupus nephritis including induction and maintenance treatment of the different histological classes, adjunctive treatment, monitoring of the patient, definitions of response and relapse, indications for (repeat) renal biopsy, and additional challenges such as the presence of vascular complications, the pregnant SLE patient, treatment in children and adolescents and considerations about end-stage renal disease and transplantation. In this review, we summarize the guidelines, determine the common ground between them, highlight the differences and discuss recent literature.

Keywords: guideline; lupus nephritis; management; systemic lupus erythematosus; treatment.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Disease Management
  • Humans
  • Kidney Failure, Chronic / complications*
  • Lupus Nephritis / etiology
  • Lupus Nephritis / therapy*
  • Practice Guidelines as Topic / standards*