Genetic variants within the serotonin transporter associated with familial risk for major depression

Ardesheer Talati; Guia Guffanti; Zagaa Odgerel; Iuliana Ionita-Laza; Heli Malm; Andre Sourander; Alan S Brown; Priya J Wickramaratne; Jay A Gingrich; Myrna M Weissman

doi:10.1016/j.psychres.2015.04.015

Genetic variants within the serotonin transporter associated with familial risk for major depression

Psychiatry Res. 2015 Jul 30;228(1):170-3. doi: 10.1016/j.psychres.2015.04.015. Epub 2015 Apr 18.

Authors

Affiliations

¹ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: talatia@nyspi.columbia.edu.
² Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: Guffant@nyspi.columbia.edu.
³ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: Odgerel@nyspi.columbia.edu.
⁴ Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA. Electronic address: ii2135@columbia.edu.
⁵ Department of Child Psychiatry, University of Turku, Turku, Finland. Electronic address: Heli.malm@hus.fi.
⁶ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Department of Child Psychiatry, University of Turku, Turku, Finland. Electronic address: Andsou@utu.fi.
⁷ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: asb11@columbia.edu.
⁸ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: wickramp@nyspi.columbia.edu.
⁹ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: jag46@columbia.edu.
¹⁰ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: mmw3@columbia.edu.

Abstract

The role of the serotonin transporter promoter linked polymorphism (5HTTLPR) in depression, despite much research, remains unclear. Most studies compare persons with and without depression to each other. We show offspring at high (N = 192) as compared to low (N = 101) familial risk for major depressive disorder were almost four times as likely to have two copies of the short allele at 5HTTLPR, suggesting that incorporation of family history could be helpful in identifying genetic differences.

Keywords: High-risk design; Serotonin transporter linked polymorphic region (5HTTLPR); rs25531.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Depressive Disorder, Major / genetics*
Genetic Predisposition to Disease*
Genotype
Humans
Pedigree
Polymorphism, Genetic
Risk
Serotonin Plasma Membrane Transport Proteins / genetics*
Severity of Illness Index

Substances

SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding