Isolation of β-indomycinone guided by cytotoxicity tests from Streptomyces sp. IFM11607 and revision of its double bond geometry

Nat Prod Commun. 2014 Sep;9(9):1327-8.

Abstract

The antibiotic β-indomycinone was isolated from Streptomyces sp. IFM11607 by cytotoxicity-guided fractionation against human gastric adenocarcinoma AGS cells, and the geometry of its δ17,18-double bond was revised from E to Z based on the coupling constant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthraquinones / chemistry*
  • Anthraquinones / isolation & purification
  • Anthraquinones / metabolism
  • Anthraquinones / pharmacology*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Humans
  • Molecular Structure
  • Streptomyces / chemistry*
  • Streptomyces / metabolism

Substances

  • Anthraquinones
  • Antineoplastic Agents