Unusual 2(1H)-pyrazinones isolated from a culture of a Brazilian marine-derived Streptomyces sp

Nat Prod Commun. 2014 Sep;9(9):1275-8.

Abstract

Four new secondary metabolites, giovaninones A-D (1-4), were isolated from an ethyl acetate extract of a culture of a marine-derived Streptomyces strain designated SS99BA-2. Chemical analysis was completely conducted in a coupled automated LC-SPE system with the use of a cryogenic NMR probehead and HRMS. The application of this system to identify, purify and elucidate all the structures is described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brazil
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pyrazines / chemistry*
  • Pyrazines / isolation & purification
  • Pyrazines / metabolism
  • Seawater / microbiology*
  • Secondary Metabolism
  • Streptomyces / chemistry
  • Streptomyces / genetics
  • Streptomyces / isolation & purification
  • Streptomyces / metabolism*

Substances

  • Pyrazines