A prospective, randomized placebo-controlled clinical trial on the effects of a fluoride rinse on white spot lesion development and bleeding in orthodontic patients

Eur J Oral Sci. 2015 Jun;123(3):186-93. doi: 10.1111/eos.12186. Epub 2015 Apr 25.

Abstract

Demineralizations around orthodontic brackets are a main disadvantage of orthodontic treatment. Several methods have been advocated to prevent their development, such as fluoride rinses or varnishes. In this randomized clinical trial, a fluoride rinse (a combination of sodium fluoride and amine fluoride) was compared with a placebo rinse, to be used every evening after toothbrushing. A total of 81 participants (mean age: 13.3 yr) completed the study (mean treatment period: 24.5 months). Demineralizations, measured using quantitative light-induced fluorescence and the decayed, missing, and filled surfaces (DMFS) index, were assessed before treatment (baseline) and around 6 wk after debonding (post treatment). Bleeding scores were measured at baseline, and during and post treatment. The incidence rate ratio for demineralizations was 2.6 (95% CI: 1.1-6.3) in the placebo group vs. the fluoride group. In the fluoride group, 31% of participants developed at least one demineralization, compared with 47% in the placebo group. Relative to baseline, gingival bleeding increased significantly in the placebo group 1 yr after the start of treatment and onwards. For the fluoride group, bleeding scores during treatment were not different from those at baseline. In conclusion, using a fluoride rinse helps to maintain better oral health during fixed appliance treatment, resulting in fewer demineralizations.

Keywords: caries prevention; fixed orthodontic appliances; fluoride rinse; gingival bleeding; tooth demineralization.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Cariostatic Agents / administration & dosage
  • Cariostatic Agents / therapeutic use*
  • Child
  • DMF Index
  • Dental Caries / prevention & control*
  • Diamines / administration & dosage
  • Diamines / therapeutic use
  • Drug Combinations
  • Female
  • Fluorescence
  • Fluorides / administration & dosage
  • Fluorides / therapeutic use*
  • Follow-Up Studies
  • Gingival Hemorrhage / prevention & control*
  • Humans
  • Male
  • Mouthwashes / therapeutic use*
  • Orthodontic Brackets*
  • Placebos
  • Prospective Studies
  • Single-Blind Method
  • Sodium Fluoride / administration & dosage
  • Sodium Fluoride / therapeutic use
  • Toothbrushing / methods

Substances

  • Cariostatic Agents
  • Diamines
  • Drug Combinations
  • Mouthwashes
  • Placebos
  • Olaflur
  • Sodium Fluoride
  • Fluorides