Sandensone A, a novel sesquiterpenoid from the Formosan soft coral Sinularia sandensis

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2353-5. doi: 10.1016/j.bmcl.2015.04.022. Epub 2015 Apr 12.

Abstract

A chromatographic and NMR spectroscopy-based fractionation on the acetone extracts of the soft coral Sinularia sandensis led to the isolation of a novel sesquiterpenoid, sandensone A (1). The structure of 1 was elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as HRESIMS spectrometry. The absolute configuration at C-12 of 1 was determined as R using a modified Mosher's method. The cytotoxicity against A549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus) were evaluated in vitro.

Keywords: Antiviral activity; Cytotoxicity; HCMV (human cytomegalovirus); Sesquiterpenoid; Sinularia sandensis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Cell Line, Tumor
  • Cytomegalovirus
  • Humans
  • Mice
  • Models, Molecular
  • Sesquiterpenes / chemistry*

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Sesquiterpenes
  • sandensone A