Tailoring specialized metabolite production in streptomyces

Jana K Hiltner; Iain S Hunter; Paul A Hoskisson

doi:10.1016/bs.aambs.2015.02.002

Tailoring specialized metabolite production in streptomyces

Adv Appl Microbiol. 2015:91:237-55. doi: 10.1016/bs.aambs.2015.02.002. Epub 2015 Mar 11.

Authors

Jana K Hiltner¹, Iain S Hunter², Paul A Hoskisson¹

Affiliations

¹ Strathclyde Institute of Pharmacy and Biological Science, University of Strathclyde, Glasgow, UK.
² Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

PMID: 25911235
DOI: 10.1016/bs.aambs.2015.02.002

Abstract

Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.

Keywords: Antibiotics; Evolution; Metabolic engineering; Metabolism; Streptomyces.

Publication types

Review

MeSH terms

Genome, Bacterial
Metabolic Engineering
Metabolic Networks and Pathways
Streptomyces / genetics
Streptomyces / metabolism*
Synthetic Biology