Feasibility of terahertz reflectometry for discrimination of human early gastric cancers

Young Bin Ji; Chan Hyuk Park; Hyunki Kim; Sang-Hoon Kim; Gyu Min Lee; Sam Kyu Noh; Tae-In Jeon; Joo-Hiuk Son; Yong-Min Huh; Seungjoo Haam; Seung Jae Oh; Sang Kil Lee; Jin-Suck Suh

doi:10.1364/BOE.6.001398

Feasibility of terahertz reflectometry for discrimination of human early gastric cancers

Biomed Opt Express. 2015 Mar 23;6(4):1398-406. doi: 10.1364/BOE.6.001398. eCollection 2015 Apr 1.

Authors

Young Bin Ji¹, Chan Hyuk Park², Hyunki Kim³, Sang-Hoon Kim⁴, Gyu Min Lee⁵, Sam Kyu Noh⁶, Tae-In Jeon⁷, Joo-Hiuk Son⁸, Yong-Min Huh⁹, Seungjoo Haam¹⁰, Seung Jae Oh¹¹, Sang Kil Lee¹², Jin-Suck Suh⁹

Affiliations

¹ Yonsei Institute of Convergence Technology, Yonsei University, Seoul 120-752, South Korea ; These authors contributed equally to this work.
² Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, 120-752, South Korea ; These authors contributed equally to this work.
³ Department of Pathology, Yonsei University College of Medicine, Seoul 120-752, South Korea.
⁴ YUMC-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul 120-752, South Korea.
⁵ Graduate Program for Nanomedical Science, Yonsei University, Seoul 120-749, South Korea.
⁶ Nano Materials Evaluation Center, Korea Research Institute of Standards and Science, Daejeon 305-340, South Korea.
⁷ Division of Electrical and Electronics Engineering, Korea Maritime University, Busan 606-791, South Korea.
⁸ Department of Physics, University of Seoul, Seoul 130-743, South Korea.
⁹ YUMC-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul 120-752, South Korea ; Department of Radiology, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 120-752, South Korea.
¹⁰ Yonsei Institute of Convergence Technology, Yonsei University, Seoul 120-752, South Korea ; Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea.
¹¹ YUMC-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul 120-752, South Korea ; issac@yuhs.ac.
¹² Division of Gastroenterology, Department of Internal Medicine, Severance Hospital, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, 120-752, South Korea ; sklee@yuhs.ac.

Abstract

We have investigated the feasibility of THz time-domain reflectometry for the discrimination of human early gastric cancer (EGC) from the normal gastric region. Eight fresh EGC tissues, which were resected by endoscopic submucosal dissection, were studied. Of them, six lesions were well discriminated on THz images and the regions well correlated with tumor regions on pathologically mapped images. Four THz parameters could be suggested for quantitative discrimination of EGCs.

Keywords: (170.2680) Gastrointestinal; (170.3880) Medical and biological imaging; (170.6510) Spectroscopy, tissue diagnostics; (170.6795) Terahertz imaging; (300.6495) Spectroscopy, terahertz.