Although the pathogenesis of glaucoma is complicated and multifactorial, elevated intraocular pressure (IOP) remains the most important known risk factor. The higher the IOP and the larger the IOP fluctuation, the more damage to the optic nerve. IOP fluctuation can be affected by many factors, such as emotion, exercise and circadian rhythm, etc. Recently, the effects of postural change on IOP fluctuation are receiving more and more attention. This article reviews the effects of different body positions on IOP fluctuation, the effects of surgery, medications and aging on posture-induced IOP fluctuation and the effects of postural change on IOP fluctuation of certain special groups. The possible mechanisms of posture-induced IOP fluctuation are also discussed in this article.