Abstract
In the article the incidence, pathogenesis, clinical featuries, diagnostic, prevention and treatment of NSAIDs-induced injuries of small intestine are presented. The different strategies of management of NSAID-induced enteropathy, such as use of PPI, COX-2-inhibitors, prostaglandins, antibiotics and probiotics, new combination of NSAIDs with phosphatidylcholine, NO or H2S, food supplements and other drugs are discussed.
MeSH terms
-
Alanine / analogs & derivatives
-
Alanine / therapeutic use
-
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
-
Cyclooxygenase 2 Inhibitors / therapeutic use
-
Gastroenteritis / chemically induced
-
Gastroenteritis / drug therapy*
-
Gastroenteritis / pathology
-
Gastrointestinal Agents / therapeutic use*
-
Humans
-
Hydrogen Sulfide / therapeutic use
-
Inflammatory Bowel Diseases / chemically induced
-
Inflammatory Bowel Diseases / drug therapy*
-
Inflammatory Bowel Diseases / pathology
-
Intestine, Small / drug effects*
-
Intestine, Small / pathology
-
Metronidazole / therapeutic use
-
Nitric Oxide Donors / therapeutic use
-
Phosphatidylcholines / therapeutic use
-
Probiotics / therapeutic use
-
Proton Pump Inhibitors / therapeutic use
-
Quinolones / therapeutic use
-
Sulfasalazine / therapeutic use
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Cyclooxygenase 2 Inhibitors
-
Gastrointestinal Agents
-
Nitric Oxide Donors
-
Phosphatidylcholines
-
Proton Pump Inhibitors
-
Quinolones
-
Metronidazole
-
Sulfasalazine
-
rebamipide
-
Alanine
-
Hydrogen Sulfide