Immune Mechanisms Are Major Players in Cancer

Karl Erik Hellstrom; Ingegerd Hellstrom

doi:10.1158/1078-0432.CCR-15-0531

Immune Mechanisms Are Major Players in Cancer

Clin Cancer Res. 2015 Aug 15;21(16):3581-3. doi: 10.1158/1078-0432.CCR-15-0531. Epub 2015 Apr 22.

Authors

Karl Erik Hellstrom¹, Ingegerd Hellstrom²

Affiliations

¹ Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington. hellsk@u.washington.edu.
² Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington.

Abstract

Vaccination with sipuleucel-T produced IgG antibodies to secondary prostatic carcinoma antigens and prolonged survival in some patients, and assaying for antibodies may provide prognostic information and identify new vaccine targets. Additional approaches to improve T-cell responses are needed to improve the clinical efficacy. See related article by GuhaThakurta et al., p. 3619.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antigens, Neoplasm / blood*
Humans
Immunity, Humoral / immunology*
Immunoglobulin G / blood*
Male
Prostatic Neoplasms, Castration-Resistant / blood*

Substances

Antigens, Neoplasm
Immunoglobulin G

Abstract

Publication types

MeSH terms

Substances

Grants and funding