Self-propelled carbon nanotube based microrockets for rapid capture and isolation of circulating tumor cells

Nanoscale. 2015 May 21;7(19):8684-8. doi: 10.1039/c5nr01797a.

Abstract

Here, we report a non-invasive strategy for isolating cancer cells by autonomously propelled carbon nanotube (CNT) microrockets. H2O2-driven oxygen (O2) bubble-propelled microrockets were synthesized using CNT and Fe3O4 nanoparticles in the inner surface and covalently conjugating transferrin on the outer surface. Results show that self-propellant microrockets can specifically capture cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ferrosoferric Oxide / chemistry
  • HCT116 Cells
  • Humans
  • Hydrogen Peroxide / chemistry
  • Ligands
  • Magnetite Nanoparticles / chemistry
  • Microscopy, Electron, Transmission
  • Nanotubes, Carbon / chemistry*
  • Neoplastic Cells, Circulating / chemistry*
  • Oxygen / chemistry
  • Surface Properties
  • Time-Lapse Imaging

Substances

  • Ligands
  • Magnetite Nanoparticles
  • Nanotubes, Carbon
  • Hydrogen Peroxide
  • Oxygen
  • Ferrosoferric Oxide