Proteus mirabilis: The Enemy Within

Amiran Dzutsev; Giorgio Trinchieri

doi:10.1016/j.immuni.2015.04.004

Proteus mirabilis: The Enemy Within

Immunity. 2015 Apr 21;42(4):602-4. doi: 10.1016/j.immuni.2015.04.004.

Authors

Amiran Dzutsev¹, Giorgio Trinchieri²

Affiliations

¹ Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
² Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: trinchig@mail.nih.gov.

PMID: 25902478
DOI: 10.1016/j.immuni.2015.04.004

Abstract

The organism needs to tailor the intestinal inflammatory response to pathogenic bacteria and to pathobionts that are only occasionally pathogenic. In this issue of Immunity, Seo et al. (2015) show that the pathobiont Proteus mirabilis induces NLRP3 inflammasome-dependent interleukin-1β (IL-1β) release from CCR2(+) Ly6C(high) inflammatory monocytes.

Publication types

Comment

MeSH terms

Animals
Carrier Proteins / immunology*
Inflammasomes / immunology*
Interleukin-1beta / immunology*
Microbiota / immunology*
Monocytes / immunology*
Symbiosis / immunology*

Substances

Carrier Proteins
Inflammasomes
Interleukin-1beta