Synthesis of 2-(1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-ones from diaminoglyoxime-based nitrones

Mol Divers. 2015 Aug;19(3):501-10. doi: 10.1007/s11030-015-9588-0. Epub 2015 Apr 22.

Abstract

Various 2-[5-(aryl)-1,2,4-oxadiazol-3-yl]quinazolin-4(3H)-ones have been synthesized from the reaction of diaminoglyoxime-based nitrones with methyl 2-aminobenzoate or 2-aminobenzamide in the presence of acetic acid at 100 °C. The reaction was extended as a one-pot three-component approach starting from diaminoglyoxime, aldehyde and methyl 2-aminobenzoate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Aminobenzoates / chemistry
  • Chemistry Techniques, Synthetic
  • Models, Molecular
  • Molecular Conformation
  • Nitrogen Oxides / chemistry*
  • Oximes / chemistry*
  • Quinazolinones / chemical synthesis*
  • Quinazolinones / chemistry*

Substances

  • Aldehydes
  • Aminobenzoates
  • Nitrogen Oxides
  • Oximes
  • Quinazolinones
  • diaminoglyoxime
  • nitrones