Diketopiperazines, inhibitors of sterol O-acyltransferase, produced by a marine-derived Nocardiopsis sp. KM2-16

J Antibiot (Tokyo). 2015 Oct;68(10):638-41. doi: 10.1038/ja.2015.38. Epub 2015 Apr 22.

Authors

Keisuke Kobayashi¹, Takashi Fukuda¹, Takeshi Terahara², Enjuro Harunari², Chiaki Imada², Hiroshi Tomoda¹

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
² Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.

PMID: 25899127
DOI: 10.1038/ja.2015.38

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinomycetales / chemistry*
Actinomycetales / metabolism*
Animals
CHO Cells
Cricetinae
Cricetulus
Diketopiperazines / metabolism
Diketopiperazines / pharmacology*
Endoplasmic Reticulum / enzymology
Enzyme Inhibitors / metabolism
Enzyme Inhibitors / pharmacology*
Molecular Conformation
Sterol O-Acyltransferase / antagonists & inhibitors*
Tetrazolium Salts
Thiazoles

Substances

Diketopiperazines
Enzyme Inhibitors
Tetrazolium Salts
Thiazoles
Sterol O-Acyltransferase
thiazolyl blue