New strategies for rapid (18)F-radiolabeling of biomolecules for radionuclide-based in vivo imaging

Jun-Liang Zeng; Jian Wang; Jun-An Ma

doi:10.1021/acs.bioconjchem.5b00180

New strategies for rapid (18)F-radiolabeling of biomolecules for radionuclide-based in vivo imaging

Bioconjug Chem. 2015 Jun 17;26(6):1000-3. doi: 10.1021/acs.bioconjchem.5b00180. Epub 2015 May 19.

Authors

Jun-Liang Zeng¹, Jian Wang², Jun-An Ma¹

Affiliations

¹ †Department of Chemistry, Key Laboratory of Systems Bioengineering (the Ministry of Education), Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, P. R. China.
² ‡Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P. R. China.

PMID: 25898224
DOI: 10.1021/acs.bioconjchem.5b00180

Abstract

The increasing availability of highly active no-carrier-added [(18)F]-fluoride makes its use in radiolabeling biomolecules attractive. By incorporating "fluorophilic" elements (Si, B, and Al) into biomolecules, recent advances offer mild and rapid (18)F-labeling approaches without HPLC purification at the radiosynthetic stage while maintaining sufficient specific activity. In this Topical Review, we will discuss the most recent strides in the field.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aluminum / chemistry
Animals
Boron / chemistry
Chromatography, High Pressure Liquid / methods
Fluorides / chemistry
Fluorine Radioisotopes / chemistry*
Humans
Isotope Labeling / economics
Isotope Labeling / methods*
Positron-Emission Tomography / economics
Positron-Emission Tomography / methods*
Silicon / chemistry
Time Factors

Substances

Fluorine Radioisotopes
Aluminum
Boron
Fluorides
Silicon