Cell competition: dying for communal interest

Maximilien Courgeon; Nikolaos Konstantinides; Claude Desplan

doi:10.1016/j.cub.2015.02.047

Cell competition: dying for communal interest

Curr Biol. 2015 Apr 20;25(8):R339-41. doi: 10.1016/j.cub.2015.02.047.

Authors

Maximilien Courgeon¹, Nikolaos Konstantinides¹, Claude Desplan²

Affiliations

¹ Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.
² Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA; Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi 129188, UAE. Electronic address: cd38@nyu.edu.

Abstract

Viable but slower growing cells are eliminated during embryonic development through the process of cell competition. Two new studies highlight a role for cell competition during adulthood as a surveillance mechanism that ensures tissue integrity during homeostasis, regeneration, and aging.

Grants and funding

R01 EY013012/EY/NEI NIH HHS/United States