Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion

L N Maslov; A V Mukhomedzyanov; S Yu Tsibulnikov; E I Chauski; I G Khaliulin; A G Portnichenko

doi:10.1007/s10517-015-2848-2

Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion

Bull Exp Biol Med. 2015 Apr;158(6):729-31. doi: 10.1007/s10517-015-2848-2. Epub 2015 Apr 21.

Authors

L N Maslov¹, A V Mukhomedzyanov, S Yu Tsibulnikov, E I Chauski, I G Khaliulin, A G Portnichenko

Affiliation

¹ Research Institute of Cardiology, Tomsk, Russia, Maslov@cardio-tomsk.ru.

PMID: 25894770
DOI: 10.1007/s10517-015-2848-2

Abstract

MEK, PI3, p38, tyrosine, and mTOR kinases are not involved in the regulation of heart resistance to the arrhythmogenic action of short-term ischemia/reperfusion in non-adapted rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arrhythmias, Cardiac / enzymology*
Arrhythmias, Cardiac / etiology*
Flavonoids / pharmacology
Imidazoles / pharmacology
MAP Kinase Kinase Kinases / antagonists & inhibitors
MAP Kinase Kinase Kinases / metabolism*
Myocardial Reperfusion Injury / complications*
Myocardial Reperfusion Injury / enzymology*
Phosphatidylinositol 3-Kinases / metabolism*
Phosphoinositide-3 Kinase Inhibitors
Pyridines / pharmacology
Rats
Rats, Wistar
Sirolimus / pharmacology
TOR Serine-Threonine Kinases / antagonists & inhibitors
TOR Serine-Threonine Kinases / metabolism*
p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases / metabolism*

Substances

Flavonoids
Imidazoles
Phosphoinositide-3 Kinase Inhibitors
Pyridines
TOR Serine-Threonine Kinases
p38 Mitogen-Activated Protein Kinases
MAP Kinase Kinase Kinases
SB 203580
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Sirolimus