A new anthraquinone from seed of Cassia obtusifolia

Nat Prod Res. 2016;30(1):35-41. doi: 10.1080/14786419.2015.1032280. Epub 2015 Apr 20.

Abstract

Seeds of Cassia obtusifolia L. are known as homology of medicine and food material, which is a commonly consumed beverage in China. One new compound, 8-hydroxy-1,7-dimethoxy-3-methylanthracene-9,10-dione-2-O-β-d-glucoside (1), together with 11 known compounds, including seven anthraquinones (2-8), was isolated from the seeds. The 2D NMR data of compound 2 are reported for the first time. The structures of the compounds were established on the basis of 1D and 2D NMR, IR and HR-ESI-MS spectra. The cytotoxic activities of all the compounds against five cell lines (LO2, HCT-116, A549, HepG2 and SGC7901) were evaluated by using CCK8 methods. Compounds 1, 3 and 7 show moderate cytotoxicity towards HCT-116 cells compared with oxaliplatin.

Keywords: Cassia obtusifolia; anthraquinone; antineoplastic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification*
  • Anthraquinones / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cassia / chemistry*
  • Cell Line, Tumor / drug effects
  • China
  • Drug Screening Assays, Antitumor / methods
  • Glucosides / chemistry
  • Glucosides / pharmacology
  • HCT116 Cells / drug effects
  • Hep G2 Cells / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Organoplatinum Compounds / pharmacology
  • Oxaliplatin
  • Seeds / chemistry*
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • 8-hydroxy-1,7-dimethoxy-3-methylanthracene-9,10-dione-2-O-beta-D-glucoside
  • Anthraquinones
  • Antineoplastic Agents, Phytogenic
  • Glucosides
  • Organoplatinum Compounds
  • Oxaliplatin