Abstract
Seeds of Cassia obtusifolia L. are known as homology of medicine and food material, which is a commonly consumed beverage in China. One new compound, 8-hydroxy-1,7-dimethoxy-3-methylanthracene-9,10-dione-2-O-β-d-glucoside (1), together with 11 known compounds, including seven anthraquinones (2-8), was isolated from the seeds. The 2D NMR data of compound 2 are reported for the first time. The structures of the compounds were established on the basis of 1D and 2D NMR, IR and HR-ESI-MS spectra. The cytotoxic activities of all the compounds against five cell lines (LO2, HCT-116, A549, HepG2 and SGC7901) were evaluated by using CCK8 methods. Compounds 1, 3 and 7 show moderate cytotoxicity towards HCT-116 cells compared with oxaliplatin.
Keywords:
Cassia obtusifolia; anthraquinone; antineoplastic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Cassia / chemistry*
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Cell Line, Tumor / drug effects
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China
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Drug Screening Assays, Antitumor / methods
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Glucosides / chemistry
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Glucosides / pharmacology
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HCT116 Cells / drug effects
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Hep G2 Cells / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Organoplatinum Compounds / pharmacology
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Oxaliplatin
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Seeds / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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8-hydroxy-1,7-dimethoxy-3-methylanthracene-9,10-dione-2-O-beta-D-glucoside
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Anthraquinones
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Antineoplastic Agents, Phytogenic
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Glucosides
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Organoplatinum Compounds
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Oxaliplatin