A new triterpenoid compound from stems and leaves of American ginseng

Liu Han; Zhuo Li; Qian Zheng; Jin-Ping Liu; Ping-Ya Li

doi:10.1080/14786419.2015.1030403

A new triterpenoid compound from stems and leaves of American ginseng

Nat Prod Res. 2016;30(1):13-9. doi: 10.1080/14786419.2015.1030403. Epub 2015 Apr 20.

Authors

Liu Han¹, Zhuo Li¹, Qian Zheng¹, Jin-Ping Liu¹, Ping-Ya Li¹

Affiliation

¹ a Institute of Frontier Medical Science, Jilin University , Changchun 130021 , P.R. China.

PMID: 25894541
DOI: 10.1080/14786419.2015.1030403

Abstract

A new dammarane-type triterpenoid compound was isolated from stems and leaves of American ginseng. The structure of the new sapogenin was elucidated by the combined analysis of NMR and HR-ESI-MS as dammar-20S, 25S-epoxy-3β, 12β, 26-triol (1). Compound 1 showed cytotoxic effect on human SM7721 and human Hela cells in vitro.

Keywords: 12β; 25S-epoxy-3β; 26-triol; cytotoxic effect; dammar-20S; dammarane-type triterpene; stems and leaves of American ginseng.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Dammaranes
Drug Screening Assays, Antitumor
HeLa Cells / drug effects
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Panax / chemistry*
Plant Leaves / chemistry*
Plant Stems / chemistry*
Triterpenes / chemistry*
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Triterpenes
dammar-20S, 25S-epoxy-3beta, 12beta, 26-triol