Dendrimeric siRNA for Efficient Gene Silencing

Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6740-4. doi: 10.1002/anie.201412493. Epub 2015 Apr 17.

Abstract

Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(β-amino ester), PBAE) to generate stable nanostructures about 160 nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.

Keywords: dendrimeric nanostructures; gene silencing; poly(β-amino ester); polymeric condensation; siRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendrimers / chemistry*
  • Gene Silencing*
  • Nanostructures / chemistry
  • Polymers / chemistry
  • RNA, Small Interfering / chemistry*
  • RNA, Small Interfering / genetics*

Substances

  • Dendrimers
  • Polymers
  • RNA, Small Interfering
  • poly(beta-amino ester)