High-fidelity noncovalent synthesis of hydrogen-bonded macrocyclic assemblies

Carlos Montoro-García; Jorge Camacho-García; Ana M López-Pérez; Nerea Bilbao; Sonia Romero-Pérez; María J Mayoral; David González-Rodríguez

doi:10.1002/anie.201501321

High-fidelity noncovalent synthesis of hydrogen-bonded macrocyclic assemblies

Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6780-4. doi: 10.1002/anie.201501321. Epub 2015 Apr 17.

Authors

Carlos Montoro-García¹, Jorge Camacho-García¹, Ana M López-Pérez¹, Nerea Bilbao¹, Sonia Romero-Pérez¹, María J Mayoral¹, David González-Rodríguez²

Affiliations

¹ Nanostructured Molecular Systems and Materials group Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid (Spain).
² Nanostructured Molecular Systems and Materials group Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid (Spain). david.gonzalez.rodriguez@uam.es.

PMID: 25891372
DOI: 10.1002/anie.201501321

Abstract

A hydrogen-bonded cyclic tetramer is assembled with remarkably high effective molarities from a properly designed dinucleoside monomer. This self-assembled species exhibits an impressive thermodynamic and kinetic stability and is formed with high fidelities within a broad concentration range.

Keywords: chelates; noncovalent interactions; nucleosides; self-assembly; supramolecular chemistry.