Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis

Bioorg Med Chem Lett. 2015;25(10):2082-8. doi: 10.1016/j.bmcl.2015.03.085. Epub 2015 Apr 4.

Abstract

For the first time, a series of tertiary amides of polyether antibiotic-Salinomycin have been obtained and screened for their antibacterial activity against different strains of bacteria, including Bacillus anthracis and clinical methicillin-resistant Staphylococcus epidermidis (MRSE). Moreover, biofilm inhibition of MRSE and genotoxicity tests against Bacillus subtilis have been performed. Our studies show that Salinomycin and its some derivatives are active against tested bacteria and exhibited definitely bacteriostatic, not bactericidal activity.

Keywords: Anti-B. anthracis activity; Biofilm inhibition; Genotoxic activity; Ionophores; Salinomycin derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus anthracis / drug effects*
  • Biofilms / drug effects
  • Drug Resistance, Bacterial
  • Pyrans / chemistry
  • Pyrans / pharmacology*
  • Staphylococcus epidermidis / drug effects*

Substances

  • Amides
  • Anti-Bacterial Agents
  • Pyrans
  • salinomycin