High-resolution imaging of the central nervous system: how novel imaging methods combined with navigation strategies will advance patient care

Hamza Farooq; Helen Genis; Joseph Alarcon; Barry Vuong; Jamil Jivraj; Victor X D Yang; Julien Cohen-Adad; Michael G Fehlings; David W Cadotte

doi:10.1016/bs.pbr.2014.12.011

High-resolution imaging of the central nervous system: how novel imaging methods combined with navigation strategies will advance patient care

Prog Brain Res. 2015:218:55-78. doi: 10.1016/bs.pbr.2014.12.011. Epub 2015 Mar 14.

Authors

Hamza Farooq¹, Helen Genis¹, Joseph Alarcon¹, Barry Vuong¹, Jamil Jivraj¹, Victor X D Yang², Julien Cohen-Adad³, Michael G Fehlings⁴, David W Cadotte⁵

Affiliations

¹ Biophotonics and Bioengineering Laboratory, Department of Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada.
² Biophotonics and Bioengineering Laboratory, Department of Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada; Physical Science-Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
³ Institute of Biomedical Engineering, Ecole Polytechnique de Montréal, SensoriMotor Rehabilitation Research Team of the Canadian Institute of Health Research, Montreal, QC, Canada.
⁴ Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
⁵ Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Toronto Western Hospital, University Health Network, Toronto, ON, Canada. Electronic address: david.cadotte@mail.utoronto.ca.

PMID: 25890132
DOI: 10.1016/bs.pbr.2014.12.011

Abstract

This narrative review captures a subset of recent advances in imaging of the central nervous system. First, we focus on improvements in the spatial and temporal profile afforded by optical coherence tomography, fluorescence-guided surgery, and Coherent Anti-Stokes Raman Scattering Microscopy. Next, we highlight advances in the generation and uses of imaging-based atlases and discuss how this will be applied to specific clinical situations. To conclude, we discuss how these and other imaging tools will be combined with neuronavigation techniques to guide surgeons in the operating room. Collectively, this work aims to highlight emerging biomedical imaging strategies that hold potential to be a valuable tool for both clinicians and researchers in the years to come.

Keywords: central nervous system imaging; human imaging atlas; magnetic resonance imaging; neuronavigation; optical coherence tomography.

Publication types

Review

MeSH terms

Anatomy, Artistic
Atlases as Topic
Central Nervous System / anatomy & histology*
Central Nervous System / surgery
Diagnostic Imaging / methods*
Humans
Optical Imaging
Patient Care / instrumentation*
Patient Care / methods
Spectrum Analysis, Raman
Tomography, Optical Coherence