Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection

Fabio Natale; Bianca Bizzarri; Veronica Cardi; Aurelia Gaeta; Paola Villani; Giuseppina Liuzzi; Mario De Curtis

doi:10.1186/s13052-015-0132-8

Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection

Ital J Pediatr. 2015 Mar 31:41:26. doi: 10.1186/s13052-015-0132-8.

Authors

Fabio Natale^{1

2}, Bianca Bizzarri³, Veronica Cardi⁴, Aurelia Gaeta⁵, Paola Villani⁶, Giuseppina Liuzzi⁷, Mario De Curtis⁸

Affiliations

¹ Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. fab.natale@libero.it.
² Neonatal Intensive Care Unit, Department of Pediatrics and Child Neuropsychiatry, "Sapienza" University of Rome, V.le Regina Elena 324, 00161, Rome, Italy. fab.natale@libero.it.
³ Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. bizzarribianca@gmail.com.
⁴ Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. veronica.cardi@gmail.com.
⁵ Laboratory of Virology, Department of Public Health and Infectious Diseases, "La Sapienza" University of Rome, Rome, Italy. aurelia.gaeta@uniroma1.it.
⁶ Department of Pharmacology, IRCCS Policlinico S. Matteo, Pavia, Italy. paolavillani2003@libero.it.
⁷ I.N.M.I. Lazzaro Spallanzani, Rome, Italy. giuseppina.liuzzi@inmi.it.
⁸ Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. mario.decurtis@uniroma1.it.

Abstract

Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant's cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.

Publication types

Case Reports

MeSH terms

Adult
Antiviral Agents / administration & dosage
Antiviral Agents / pharmacology*
Antiviral Agents / therapeutic use*
Cytomegalovirus Infections / cerebrospinal fluid*
Cytomegalovirus Infections / congenital*
DNA, Viral / analysis
Female
Ganciclovir / administration & dosage
Ganciclovir / analogs & derivatives*
Ganciclovir / pharmacology
Ganciclovir / therapeutic use
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious
Valganciclovir

Substances

Antiviral Agents
DNA, Viral
Valganciclovir
Ganciclovir