The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases

Semin Arthritis Rheum. 2015 Aug;45(1):1-8. doi: 10.1016/j.semarthrit.2015.02.007. Epub 2015 Feb 20.

Abstract

Importance: TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. They constitute a cytokine system that actively interferes with the regulation of immune responses and may participate in the pathogenesis of autoimmune diseases.

Objectives: This review aims to present the current knowledge on the role of the TL1A/DR3/DcR3 system in the pathophysiology of autoimmune rheumatic diseases, with a focus on rheumatoid arthritis (RA).

Methods: An extensive literature search was performed in the PubMed database using the following keywords: TL1A, death receptor 3, DR3, decoy receptor 3, DcR3, TNFSF15, TNFRSF25, and TNFSF6B. Studies were assessed and selected in view of their relevance to autoimmune rheumatic diseases.

Conclusion: The TL1A/DR3/DcR3 axis is a novel immune pathway that participates in the pathogenesis of a variety of autoimmune rheumatic diseases. These molecules may be promising therapeutic targets for inflammatory arthritis.

Keywords: Autoimmune disease; DR3; DcR3; Rheumatic disease; TL1A.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / metabolism*
  • Humans
  • Receptors, Tumor Necrosis Factor, Member 25 / metabolism*
  • Receptors, Tumor Necrosis Factor, Member 6b / metabolism*
  • Rheumatic Diseases / immunology
  • Rheumatic Diseases / metabolism*
  • Signal Transduction / physiology
  • Tumor Necrosis Factor Ligand Superfamily Member 15 / metabolism*

Substances

  • Receptors, Tumor Necrosis Factor, Member 25
  • Receptors, Tumor Necrosis Factor, Member 6b
  • TNFRSF25 protein, human
  • TNFSF15 protein, human
  • Tumor Necrosis Factor Ligand Superfamily Member 15