Comparative Genomics of the Mucoid and Nonmucoid Strains of Streptococcus pyogenes, Isolated from the Same Patient with Streptococcal Meningitis

Haruno Yoshida; Yasuhito Ishigaki; Asako Takizawa; Kunihiko Moro; Yuki Kishi; Takashi Takahashi; Hidenori Matsui

doi:10.1128/genomeA.00221-15

Comparative Genomics of the Mucoid and Nonmucoid Strains of Streptococcus pyogenes, Isolated from the Same Patient with Streptococcal Meningitis

Genome Announc. 2015 Apr 16;3(2):e00221-15. doi: 10.1128/genomeA.00221-15.

Authors

Haruno Yoshida¹, Yasuhito Ishigaki², Asako Takizawa³, Kunihiko Moro⁴, Yuki Kishi⁴, Takashi Takahashi¹, Hidenori Matsui⁵

Affiliations

¹ Department of Infection Control and Immunology and Graduate School of Infection Control Sciences, Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
² Division of Molecular and Cell Biology, Medical Research Institute, Kanazawa Medical University, Uchinada-machi, Kahoku-gun, Ishikawa, Japan.
³ Division of Basic Research, Biomedical Laboratory, Kitasato Institute Hospital, Kitasato University, Tokyo, Japan.
⁴ Hikone Municipal Hospital, Hassaka-cho, Hikone-shi, Shiga, Japan.
⁵ Department of Infection Control and Immunology and Graduate School of Infection Control Sciences, Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan hmatsui@lisci.kitasato-u.ac.jp.

Abstract

Mucoid (MTB313) and nonmucoid (MTB314) strains of group A streptococcus emm type 1 were simultaneously isolated from a single patient suffering from streptococcal meningitis. Whole-genome sequencing revealed that MTB313 carried a nucleotide substitution within rocA, which generated an amber termination codon.