Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging

Shahriar Sharifi; Hajar Seyednejad; Sophie Laurent; Fatemeh Atyabi; Amir Ata Saei; Morteza Mahmoudi

doi:10.1002/cmmi.1638

Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging

Contrast Media Mol Imaging. 2015 Sep-Oct;10(5):329-55. doi: 10.1002/cmmi.1638. Epub 2015 Apr 16.

Authors

Shahriar Sharifi¹, Hajar Seyednejad², Sophie Laurent^{3

4}, Fatemeh Atyabi⁵, Amir Ata Saei^{5

6}, Morteza Mahmoudi^{5

7

8}

Affiliations

¹ Department of Biomaterials Science and Technology, University of Twente, The Netherlands.
² Department of Bioengineering, Rice University, Houston, TX, 77005, USA.
³ Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, B-7000, Mons, Belgium.
⁴ CMMI - Center for Microscopy and Molecular Imaging, Rue Adrienne Bolland 8, B-6041, Gosselies, Belgium.
⁵ Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
⁷ Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
⁸ Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

PMID: 25882768
DOI: 10.1002/cmmi.1638

Abstract

In the last decade, the biomedical applications of nanoparticles (NPs) (e.g. cell tracking, biosensing, magnetic resonance imaging (MRI), targeted drug delivery, and tissue engineering) have been increasingly developed. Among the various NP types, superparamagnetic iron oxide NPs (SPIONs) have attracted considerable attention for early detection of diseases due to their specific physicochemical properties and their molecular imaging capabilities. A comprehensive review is presented on the recent advances in the development of in vitro and in vivo SPION applications for molecular imaging, along with opportunities and challenges.

Keywords: MRI; SPIONs; cellular imaging; iron oxide; molecular imaging; superparamagnetic nanoparticles.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Ferric Compounds / chemistry*
Humans
Magnetic Resonance Imaging / methods*
Metal Nanoparticles / chemistry*

Substances

Ferric Compounds
ferric oxide