Synthesis, characterization, and application of microbe-triggered controlled-release kasugamycin-pectin conjugate

J Agric Food Chem. 2015 May 6;63(17):4263-8. doi: 10.1021/jf5055062. Epub 2015 Apr 27.

Abstract

The controlled and targeted release of pesticides with high water solubility has been a challenge for integrated pest management. In this paper, kasugamycin, an antibiotic broadly used in plant disease control, was covalently conjugated to pectin to form a kasugamycin-pectin conjugate by an amide bond. The conjugate was structurally characterized by Fourier transform infrared spectroscopy, ultraviolet spectrophotometry, and thermal gravimetric analysis. The results showed that the conjugate was stable over a wide range of pH and temperatures, as well as under UV irradiation. When incubated with Pseudomonas syringae pv. lachrymans, the conjugate could be activated, releasing the kasugamycin, which made it a promising controlled-release formulation of pesticide.

Keywords: controlled release; kasugamycin; microbe-triggered; pectin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides / chemistry
  • Aminoglycosides / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Delayed-Action Preparations / chemical synthesis*
  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / pharmacology*
  • Drug Carriers / chemistry
  • Drug Delivery Systems
  • Pectins / chemistry
  • Pesticides / chemical synthesis*
  • Pesticides / chemistry
  • Pesticides / pharmacology*
  • Plant Diseases / microbiology
  • Plant Diseases / prevention & control
  • Pseudomonas syringae / drug effects*
  • Pseudomonas syringae / physiology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Delayed-Action Preparations
  • Drug Carriers
  • Pesticides
  • Pectins
  • kasugamycin