Abstract
Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinomycetales / chemistry*
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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HeLa Cells
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Humans
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Molecular Conformation
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Quantum Theory
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Structure-Activity Relationship
Substances
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Macrolides
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saccharothriolide B