Suppression of Th2 chemokines by crocin via blocking of ERK-MAPK/NF-κB/STAT1 signalling pathways in TNF-α/IFN-γ-stimulated human epidermal keratinocytes

Exp Dermatol. 2015 Aug;24(8):634-6. doi: 10.1111/exd.12726. Epub 2015 May 8.
No abstract available

Keywords: Th2 chemokines; atopic dermatitis; crocin.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carotenoids / pharmacology*
  • Cell Line
  • Chemokines / metabolism*
  • Drug Evaluation, Preclinical
  • Epidermal Cells
  • Humans
  • Interferon-gamma / pharmacology
  • Keratinocytes / drug effects*
  • Keratinocytes / metabolism
  • MAP Kinase Signaling System / drug effects*
  • NF-kappa B / physiology
  • STAT1 Transcription Factor / physiology
  • Tumor Necrosis Factor-alpha / pharmacology

Substances

  • Chemokines
  • NF-kappa B
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Tumor Necrosis Factor-alpha
  • Carotenoids
  • Interferon-gamma
  • crocin