Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient

Chem Commun (Camb). 2015 May 11;51(38):8044-7. doi: 10.1039/c5cc01088h. Epub 2015 Apr 13.

Abstract

Intracellular thermometry at the microscopic level is currently a hot topic. Herein we describe a small molecule fluorescent thermometer targeting mitochondria (Mito thermo yellow). Mito thermo yellow successfully demonstrates the ability to monitor the intracellular temperature gradient, generated by exogenous heating, in various cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Animals
  • Cell Line
  • Fluorescence*
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Mice
  • Mitochondria / chemistry*
  • Molecular Structure
  • Temperature*
  • Thermometry / methods*
  • Xanthenes / chemistry*

Substances

  • Fluorescent Dyes
  • Mito thermo yellow
  • Xanthenes