Typologies of positive psychotic symptoms in methamphetamine dependence

Am J Addict. 2015 Mar;24(2):94-97. doi: 10.1111/ajad.12160.

Abstract

Background and objectives: Understanding methamphetamine associated psychotic (MAP) symptom typologies could aid in identifying individuals at risk of progressing to schizophrenia and guide early intervention.

Methods: Latent class analysis (LCA) of psychotic symptoms collected from 40 (n = 40) methamphetamine dependent individuals with a history of psychotic symptoms but no history of a primary psychotic disorder.

Results: Three typologies were identified. In one, persecutory delusions dominated (Type 1), in another persecutory delusions were accompanied by hallucinations (Type 2), and in the third a high frequency of all the assessed hallucinatory and delusional symptoms was observed (Type 3).

Discussion and conclusion: MAP is a heterogeneous syndrome with positive symptom typologies.

Scientific significance: This study represents the first attempt at identifying typologies of MAP and highlights the potential utility of LCA in future large-scale studies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amphetamine-Related Disorders / complications
  • Amphetamine-Related Disorders / diagnosis*
  • Amphetamine-Related Disorders / psychology*
  • Delusions / complications*
  • Delusions / psychology
  • Female
  • Hallucinations / complications*
  • Hallucinations / psychology
  • Humans
  • Male
  • Methamphetamine / adverse effects*
  • Psychoses, Substance-Induced / complications
  • Psychoses, Substance-Induced / diagnosis*
  • Psychoses, Substance-Induced / psychology
  • Symptom Assessment
  • Victoria
  • Young Adult

Substances

  • Methamphetamine