A premammillary lateral hypothalamic nuclear complex responds to hedonic but not aversive tastes in the male rat

Brain Struct Funct. 2016 May;221(4):2183-208. doi: 10.1007/s00429-015-1038-3. Epub 2015 Apr 12.

Abstract

The lateral hypothalamic area (LHA) has two major roles: arousal/waking and food intake controls. Here, it is shown that a premammillary part of the LHA is neurochemically and cytoarchitectonically distinct from the tuberal LHA in male rats. This part contains nuclear masses, namely the parasubthalamic nucleus and the calbindin nucleus, involved in pathways that predict its participation in the control of food intake. Analyzing c-Fos expression in experiments related to feeding behavior, this region responded specifically to the ingestion of palatable nutriments.

Keywords: CEA; CGRP; Feeding behavior; Insular cortex; Substance P.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arousal
  • Calbindins / metabolism
  • Central Amygdaloid Nucleus / cytology
  • Cerebral Cortex / cytology
  • Conditioning, Classical / physiology*
  • Eating
  • Feeding Behavior / physiology*
  • Glutamate Decarboxylase / metabolism
  • Hypothalamic Area, Lateral / cytology*
  • Hypothalamic Area, Lateral / metabolism*
  • Hypothalamic Hormones / metabolism
  • Male
  • Melanins / metabolism
  • Neural Pathways / cytology
  • Neural Pathways / metabolism
  • Orexins / metabolism
  • Parvalbumins / metabolism
  • Pituitary Hormones / metabolism
  • Proto-Oncogene Proteins c-fos / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Substance P / metabolism
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Calbindins
  • Hypothalamic Hormones
  • Melanins
  • Orexins
  • Parvalbumins
  • Pituitary Hormones
  • Proto-Oncogene Proteins c-fos
  • Substance P
  • melanin-concentrating hormone
  • Tyrosine 3-Monooxygenase
  • Glutamate Decarboxylase