Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase. Promising results have been showed by alkaloids californidine (IC50=55.6±3.5 μM), dihydrosanquinarine (IC50=99.1±7.6 μM), corypalmine (IC50=128.0±10.5 μM) and N-methyllaurotetanine (IC50=135.0±11.7 μM).
Keywords: Argemonine (CID: 442168); Berberine (PubChem CID: 2353); Californidine; Californidine (PubChem CID: 45266443); Canadine (PubChem CID: 443422); Corynoline (PubChem CID: 177014); Corypalmine (PubChem CID: 185605); Dihydrosanquinarine; Dihydrosanquinarine (PubChem CID: 124069); Isoquinoline alkaloids; N-Methyllaurotetanine (PubChem CID: 16573); Prolyl oligopeptidase.
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